ABSTRACT
Traditionally, overweight or obesity has a protective effect on bone quality. In recent years, more and more studies have confirmed that obesity is associated with osteoporosis. Obesity can be involve in many signaling pathways such as bone marrow apoptosis, bone formation, bone differentiation, bone microcirculation, bone resorption, and so on. Obesity can change the expression of different types of factors such as bone growth factor, proinflammatory cytokine and hormone receptor, inducing the activation of various types of transcription factors that induce osteoblast differentiation, maturation and survival, and obesity also activates the signaling pathway regulating the role of osteoclasts. This article reviews the effects and molecular mechanisms of obesity on osteogenesis, osteoclast as well as the molecular mechanisms of obesity induced osteoporosis.